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HSC aging impacts distant tissues by giving rise to myeloid cells with an inflammatory phenotype that go into the circulation, with a deleterious long-term effect (Figs

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The transcription of a set of genes related to the regulation of heme synthesis and transformation, such as heme oxygenase 1 (HO-1), ferrochelatase (FECH) and SLC48A1, is upregulated by NRF2 [100,101,102,103]

6 Conclusion Current evidence indicates that Curcuma longa and its bioactive compounds may offer potential benefits in alleviating symptoms of depression and anxiety in patients with chronic diseases, particularly those with metabolic dysfunction-associated conditions (DACD)